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Statins decrease mortality in Lebanese patients with sepsis: A multicenter study

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Author(s): Ajrouche R | Al-Hajje A | El-Helou N | Awada S | Rachidi S | Zein S | Salameh P

Journal: Pharmacy Practice
ISSN 1885-642X

Volume: 11;
Issue: 2;
Start page: 102;
Date: 2013;
Original page

Keywords: Sepsis | Hydroxymethylglutaryl-CoA Reductase Inhibitors | Mortality | Survival Analysis | Lebanon

ABSTRACT
Background: Sepsis is a significant public health concern. The clinical response to statins is variable among sepsis patients. Objective: The aim of the study was to determinate the effect of statin-treatment on mortality in Lebanese patients with sepsis.Methods: A retrospective multicenter study on Lebanese patients with sepsis between January 2008 and March 2012 was conducted. Patients with a primary diagnosis of sepsis admitted to the intensive care unit of two tertiary care hospitals in Beirut were included. Patients who continued to receive statin therapy for dyslipidemia during the hospital course were included in the statin treatment group. The control group consisted of patients not taking statin. Demographic characteristics, clinical signs, standard laboratory test and treatment received were compared between these two groups using univariate analysis. Logistic regression and survival analysis were performed by SPSS. Results: Three hundred fifty one Lebanese patients were included (age: 71.33 SD=14.97 years; Male: 56%). Among them, 30% took a statin at the doses recommended for dyslipidemia. The comparison of the two groups showed that in the statin treatment group: The mean serum level of C-reactive protein at the time of sepsis was significantly decreased (P=0.050), the length-stay at ICU significantly increased (P=0.047) and mortality significantly reduced (P
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