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Statistical Optimization of Process Parameters Influencing Biotransformation of Plant Tannin into Gallic Acid under Solid–Liquid Fermentation

Author(s): Bibhu Prasad Panda | Rintu Banerjee | Rupa Mazumder | Rupa Mazumder

Journal: Journal of Pharmacy and Bioallied Sciences
ISSN 0975-7406

Volume: 1;
Issue: 1;
Start page: 41;
Date: 2009;
Original page

Keywords: Gallic acid | Rhizopus oryzae | Evolutionary operation | Response surface methodology | solid state fermentation | chebulic myrobalan fruit

Gallic acid (3, 4, 5-trihydroxy benzoic acid), an important organic acid for synthesis of propyl gallate and trimethoprim, was produced by solid-liquid fermentation using Rhizopus oryzae NRRL 21498. Evolutionary operation (EVOP)-factorial design and response surface methodology was applied successfully to elucidate the effect of different process parameters influencing biotransformation of natural tannin (powdered chebulic myrobalan fruit) to gallic acid. At 28OC, 70% relative humidity, pH 6, 72h of fermentation period, 3ml inoculum volume and 25g substrate weight resulted maximum gallic acid yield of 93.29%.
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