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Stężenie BDNF w surowicy a nasilenie objawów depresji

Author(s): Jakub Filuś | Janusz Rybakowski

Journal: Neuropsychiatria i Neuropsychologia
ISSN 1896-6764

Volume: 5;
Issue: 3-4;
Start page: 155;
Date: 2010;
Original page

Keywords: brain-derived neurotrophic factor | BDNF | depression | Hamilton Depression Scale

Aim of the study was studying of connection betweenserum BDNF – brain derived neurotrophic factor level –in severely depressed patients, and severity of symptomsin depression.Material and methods: In studies took part 45 womenhospitalized with the diagnosis of depressive episode incourse of unipolar or bipolar disorder. Severity of depressionwas assessed with Hamilton Rating Scale forDepression (HAM-D). Serum BDNF was assayed withsandwich ELISA method using Quantikine HumanBDNF Immunoassay (R&D Systems).Results:We found statistically significant negative correlationbetween serum BDNF levels in severe depressionand severity of depression (measured with HAM-D).Statistical significance concerns the general assessment,symptoms of cluster II (depression related anxiety andinsomnia) and such symptoms as anxiety psychic,insight.Conclusions: Our results suggest correlation betweenBDNF serum level and severity of psychopathologicalsigns in depression.

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