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Stimulus Controlled Drug Delivery via Ultrasound Drug Delivery

Author(s): Dinesh Mali*, Yadunath Joshi, Vaibhav Borole and Vilasrao Kadam

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 2925;
Date: 2011;
Original page

Keywords: Targeted drug delivery | Ultrasound | Liposomes | Microbubbles | Contrast agent | Cavitations

The activity of most drugs against disease suffers from their inability to accumulate selectively at the site of action hence site specific targeting is an emergingconcept in Novel Drug Delivery System (NDDS) with the aim of enhancing the efficiency of drug by allowing the maximum fraction of drug molecule to reactexclusively with the target cells reducing the toxicity and side effects to normal cells. Stimulus controlled drug and gene delivery system creates a new set ofchallenge usually related to their large physical size. However, irrespective of size a therapeutic must safely search its target cell and the appropriate locationwithin that cell to archive its desired therapeutic effect. There are many different approaches to targeted drug delivery, being one of them ultrasound delivery(USD). Ultrasound has been used in various drug delivery applications to enhance the delivery of pharmaceuticals to target tissues, Ultrasound has been shownto facilitate the delivery of drugs across the skin, promote gene therapy to specific tissues, deliver chemotherapeutic drugs into tumors and deliver thrombolyticdrugs into blood clots. In addition, ultrasound has also been shown to facilitate the healing of wounds and bone fractures and also ultrasound contrast agent hasbeen recently developed for diagnostic ultrasound which can be used as exogenous cavitations nuclei for enhancement of drug and gene delivery. US-enhanceddelivery of proteins has found most application in transdermal delivery of insulin. This review paper summarizes the mechanisms of drug delivery, advantagesand disadvantages of US and US contrast agent there therapeutic application in site specific drug delivery. However further research, long term toxicity studyand characterization is required to ensure the improvement of magnetic drug delivery system.

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