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Stromal Cell Derived Factor-1 Genetic Variation at Locus 801 in Patients with Myasthenia Gravis

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Author(s): Gholam Ali Yousefipour | Mohammad Reza Haghshenas | Sara Yahyazadeh | Nasrollah Erfani

Journal: Iranian Journal of Immunology
ISSN 1735-1383

Volume: 8;
Issue: 2;
Start page: 90;
Date: 2011;
Original page

Keywords: Polymorphism | Myasthenia Gravis | SDF1

ABSTRACT
Background: Myasthenia gravis (MG) is the most common disorder of neuromuscular junction in which autoantibodies develop against nicotinic acetylcholine receptor for unknown reasons. The association of immunomodulator genes with different autoim-mune disease has been studied in recent years. Objective: The aim of this study was to investigate correlation between a genetic variation in Stromal Cell Derived Factor-1 (SDF1) and susceptibility to MG in an Iranian population. Methods: Genotyping of SDF1 at position 801 G/A was performed by Polymerase Chain Reaction-Restriction Length Polymorphism (PCR-RFLP) in 87 patients with confirmed myasthenia gravis and 261 normal control subjects. Results: No statistically significant differences were observed in the frequencies of genotypes and alleles between patients and controls (p>0.05). Furthermore, no significant differences in the genotype distribution were found between the cases with different stages (p>0.05). Conclusion: Our data suggest that the SDF1 gene polymorphism at position 801 G/A is not associated with myasthe-nia gravis.
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