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STRUCTURAL CHANGES IN THE RAT TESTIS CAUSED BY DIAZINON AND SELENIUM

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Author(s): Michal Cabaj | Róbert Toman | Mária Adamkovičová | Peter Massányi | Branislav Šiška | Norbert Lukáč | Jozef Golian

Journal: Potravinarstvo : Scientific Journal for Food Industry
ISSN 1338-0230

Volume: 4;
Issue: 2;
Start page: 8;
Date: 2010;
Original page

Keywords: diazinon | selenium | testis | histology | morphometry | rat

ABSTRACT
The aim of this study was to find the structural changes in the rat testis after a diazinon, selenium and their combined administration. The testis structural changes after the diazinon intraperitoneal administration of 20 mg/kg b.w., selenium 2 mg/kg b.w. and both diazinon 20 mg/kg b.w. and selenium 2 mg/kg b.w. were evaluated by histological and morphometric methods in light microscopy. 36 hours after the diazion i.p. administration, the vacuolization of the seminiferous epithelium, evacuation of germ cells into the tubule lumen, epithelium necrosis and disintegration, interstitium extension and fibrotization were observed. The germ cells released from the basal lamina and subsequently they were visible in the tubule lumen. Blood vessels were damaged and morphometric analysis have shown their significant dilatation (P
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