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STUDIES TO ENHANCE DISSOLUTION PROPERTIES OF ETORICOXIB

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Author(s): S. Muralidhar

Journal: International Journal of Pharmaceutical Research and Development
ISSN 0974-9446

Volume: 2;
Issue: 4;
Start page: 10;
Date: 2010;
Original page

Keywords: Solid dispersion | Etoricoxib | Physical mixtures | Kneading method | Solvent evaporation method | Polyvinyl pyrrolidone

ABSTRACT
Etoricoxib, a non-steroidal anti-inflammatory drug, is used to Osteoarthritis, Rheumatoid arthritis and Acute Gouty arthritis. Etoricoxib is practically insoluble in water , hence present study was carried out to enhance dissolution properties of Etoricoxib. Through the preparation of Solid Dispersions using PVPK-30, as carrier at various proportions (1:1,1:3,1:6, 1:9) by using different techniques like Physical mixtures, Kneading Method and Solvent Evaporation Method. The drug release profile was studied in 900ml.0.1N HCl containing 0.75% SLS. U.V. Spectrophotometric method was selected for assay as well as in-vitro dissolution studies at 234nm. The dispersions were evaluated for drug content uniformity dissolution rate study, DE20, T50, Reproducibility and ANOVA. The FTIR and DSC were used to characterize the solid state of solid dispersions. A marked increase in dissolution rate was observed with all solid dispersions; among that Etoricoxib with PVP K-30 (1:6) Solvent evaporation method gave highest dissolution. The increase in dissolution rate of the drug may be due to increased wettability, hydrophilic nature of the carrier and also possibility due to reduction in drug crystalinity.
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