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Studies on Antivenom Activity of Ceiba pentandra Leaves’ Aqueous Methanol Extract Against Echis ocellatus’ Snake Venom

Author(s): sarkiyayi shehu | S. Ibrahim and M.S. Abubakar

Journal: Research Journal of Applied Sciences, Engineering and Technology
ISSN 2040-7459

Volume: 2;
Issue: 7;
Start page: 687;
Date: 2010;
Original page

Keywords: Antivenom | Ceiba pentandra | Echis ocellatus | phospholipase A2 | plant | snake venom

Aqueous methanol of Ceiba pentandra leaves extract was tested for antivenom activity against Echis ocellatus snake venom. Among parameters investigated include: LD50 of the Echis ocellatus snake venom, phospholipase A2 activity, percentage hemolysis. In vivo analysis of total protein content, white blood cells, pack cell volume and haemoglobin contents were also investigated. The result reveals that Echis ocellatus has an LD50 of 0.280mg/kg ± 0.065. Haemolysis due to venom has drastically reduced by the extract from 66% to 27.4%. suggesting that the extract is effective in reducing haemolysis in mice. The in vivo studies reveals that there were significant (p

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