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Studies on hepatoprotective activity of traditional ayurvedic formulation ‘Vidakana Choornam’ against carbon tetrachloride induced hepatotoxicity in albino rat

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Author(s): Jayarama Reddy, Gnanasekaran D, Ranganathan TV and Vijay D

Journal: International Journal of Pharmaceuticals Analysis
ISSN 0975-3079

Volume: 2;
Issue: 2;
Start page: 05;
Date: 2010;
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Keywords: Vidakana Choornam | Bilirubin | Serum Glutamate Pyruvate Transaminase | Glutamate Oxaloacetate Transaminase | ALP level | hepatoprotective | Histopathology.

ABSTRACT
The study was carried out to ascertain the hepatoprotective activity of traditional ayurvedicformulation ‘Vidakana Choornam’ against carbon tetrachloride induced hepatotoxicity in albino rat. Effect ofcarbon tetrachloride and herbal products on liver weights was studied. Bilirubin level in serum, SerumGlutamate Pyruvate Transaminase (GPT) level in serum, Serum Glutamate Oxaloacetate Transaminase(GOT) level in serum and ALP level in serum were estimated in both control treatment. Histopathologicalstudies were also carried out. It was found that there was an increase in liver weight during carbontetrachloride treatment which may be due to accumulation of fat. The results of Vidakana Choornam’treatment against carbon tetrachloride induced hepatotoxicity revealed that there was considerablereduction in Bilirubin level in serum, Serum Glutamate Pyruvate Transaminase (GPT) level in serum, SerumGlutamate Oxaloacetate Transaminase (GOT) level in serum and ALP level in serum. The hepatoprotectiveactivity of this simple formulation was found to be as effective as Liv – 52, infact the activity on decreasingthe serum bilirubin level was much higher when compared to Liv – 52
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