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Studies on Phytochemical Investigation And Hypoglycemic Evaluation of Azadirachta Indica Leaves Extract on Alloxan Induced Diabetic Rats

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Author(s): Alok Maithani1, Versha Parcha*2, Geeta Pant3, Ishan Dhulia2, and Deepak Kumar2.

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 3;
Start page: 759;
Date: 2011;
Original page

Keywords: Azadirachta indica | Diabetes | Hypoglycemia | Alloxan | Glibenclamide

ABSTRACT
Effect of different extracts of leaves of Azadirachta indica on lowering blood glucose level on intraperetoneally administered alloxan induced diabetic rats were investigated. A significantinhibition in fasting blood glucose level by aqueous extract of eaves of Azadirachta indica was observed when compared with control group and with standard drug glibenclamide. The extracts of leaves of Azadirachta indica were also evaluated for the availability of hytoconstituents for presence of tannins, steroids, saponins, arbohydrates, and polyphenols etc. The present study ascertained that the aqueous extract of Azadirachta indica leaves possesses significant anti-hyperglycemic potential which may be due to the phytoconstituents present in the aqueous extracts

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