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A study of adverse drug reaction on drugs used in the management of type 2 diabetic mellitus

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Author(s): K. Saravanan*, Dr. P.K. Manna, Dr. G.P. Mohanta, Dr. R. Manavalan

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 10;
Start page: 3394;
Date: 2011;
Original page

Keywords: Adverse Drug Reaction | Diabetics Mellitus | Rational Use of Drug

ABSTRACT
Adverse drug reaction is defined by WHO as any response to a drug which is noxious and unintended, and which occurs at doses used in man for the prophylaxis,diagnosis or therapy of disease or for the modification of physiological function. This prospective observational study was carried out in the multispecialty tertiarycare teaching hospital attached to the Annamalai University, Annamalai Nagar with an aim to study the adverse drug reactions of drugs used in the managementof patients with type-2 diabetes mellitus. Study enrolled 75 patients treated with oral hypoglycemic agents both as mono therapy (Glimepride, Metformine andPioglitazone) and as combination therapy (Glimepride + Metformine). The study result showed that the adverse drug reactions were observed in 35 patients(46.66%) and most of them were male (27 out of 35). Adverse drug reactions that were observed during the study were classified as Type A (Hypoglycemic,Diarrhea, Vomiting, Giddiness, Abdominal Distension: 23/75), Type C (Allergic Skin Reaction, Sweating: 3/75), Type H (Edema, Gastric Irritation: 3/75) and TypeU (Headache: 6/75) as per the WHO classification. The study revealed that the incidence of adverse drug reactions were higher in patients treated with Glimepride(16/35), compared to those patients treated with Metformine (10/35), Pioglitazone (5/35) and combination of Glimepride + Metformine (4/35).
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