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Study of antimicrobials in post-operative wound infection after emergency gastrointestinal surgery

Author(s): R.T Saravanakumar*1, Dr. G.P. Mohanta1, Dr. P.K. Manna1, Dr. V.R. Baskaran2, C.Moorthi1, Dr. R. Manavalan1

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 3079;
Date: 2011;
Original page

Keywords: Post-operative | Wound Infection | Emergency Gastrointestinal Surgery | Appendicitis | Amikacin

Infection of the operative incision is a common post-operative complication which leads to significant post-operative morbidity, mortality, prolongs hospitalstay, adds to hospital cost and also blocks other needing patients to get admitted in the ward. The primary aim of this study was to evaluate the antimicrobialusage in post-operative wound infection after emergency gastrointestinal surgery with objectives to assess the prevalence of post-operative wound infection,to assess the prevalence of different microorganisms and its sensitivity pattern to commonly used antibiotics. A total of 550 patients with emergencygastrointestinal surgeries, who met all inclusion criteria and none of the exclusion criteria were included in the study. Out of the 550 patients, 56 patients hadpost-operative wound infections. Prevalence of wound infection was higher in Appendicitis than in other emergency gastrointestinal surgeries. Pathogens thatare prevalent in post-operative wound infection are Staphylococcus aureus (Appendicitis, Ileal Perforation, Sigmoid Volvulus, Duodenal Perforation, andObstructed Hernia), Klebsiella (Appendicitis and Duodenal Perforation), Escherichia coli (Appendicitis) and Pseudomonas (Obstructed Hernia and SigmoidVolvulus). Isolated pathogens were tested for its sensitivity against commonly used antibiotics at the hospital. Antimicrobial Amikacin was sensitive to allisolated pathogens with very low resistance profile compare to other commonly used antimicrobial at hospital.
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