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STUDY OF EFFECT OF ADVANCED MATERNAL AGE RELATED RISKS FOR DOWN SYNDROME & OTHER TRISOMIES.

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Author(s): kinnar somabhai desai | Neha Harjivanbhai Pandya | Amita Mevada | Vaishali Patel | toral goswami | Mitesh Suthar

Journal: International Journal of Biomedical and Advance Research
ISSN 2229-3809

Volume: 4;
Issue: 2;
Start page: 123;
Date: 2013;
Original page

Keywords: chromosomal abnormalities | cytogenetic study | down syndrome | karyotype | maternal age | meiotic division |

ABSTRACT
ABSTRACTBack ground: Down syndrome is the most frequent live born aneuploidy & recognizable form of mental retardation among all the ethnic groups of human population across the globe. The most common risk factor for DS is advanced maternal age. The aim of this study was to find out risks of advanced maternal age for chromosomal abnormalities.  Materials & methods: The chromosomal abnormalities were diagnosed by cytogenetic study of 30 clinically diagnosed cases of DS attending paediatric outpatient department(OPD) & admitted in paediatric ward, Civil Hospital, Ahmedabad, as well as cases from B.M. Institute of Mental Health, Aashram Road, Ahmedabad. Their detailed history was taken.Results: The study revealed that with advanced maternal age the risk of child birth having DS was increased. After age of 35 years the risk of child birth with DS was increased by 43.4% in our study.Conclusion: As a woman gets older, her risk to have a pregnancy with a chromosome abnormality increases. The most commonly used definition for advanced maternal age is 35 years or more at time of child birth. With advanced maternal age hormonal level, numbers of healthy oocyte for fertilization, telomere length decreases with reduced meiotic recombination. All these factors increases the risk of pregnancy with DS.
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