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Study Of Factors Predicting Therapeutic Response In Multiple Myeloma

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Author(s): Binu sasidharan 1, Prem Kotian 2, Jagannath Kamath B 3, Deepak Jayaram 4, Krishnaprasad 5, Vandana Vamadevan 6, Muralikrishnan, Kannampillil 7, Vijay Tubaki 8, Vishal Mangrolia 9, Anup Kumar 10

Journal: Journal of Orthopaedics
ISSN 0972-978X

Volume: 5;
Issue: 1;
Date: 2008;
Original page

Keywords: multiple myeloma | therapeutic response

ABSTRACT
Ever since William McIntyre 1 gave the first description of multiple myeloma(MM) in 1850,this disease has been an area of constant research because of the plethora of symptoms by which the disease can present, lack of effective treatment and poor prognosis.Multiple myeloma which accounts for 1% of all malignancies represents an unrestrained proliferation of a single clone of plasma cells leading to increased production of immunoglobins which are structurely abnormal and functionally incompetent. Last four decades has seen great progress in understanding the diagnosis and treatment of this deadly condition.A major breakthrough happened in 1958 when Blokhin of Russia reported the successful use of a racemic mixture of D and L phenylalanine mustards (Melphalan) in the management of myeloma 1. The most widely used staging system in multiple myeloma is the Durie Salmon staging 2which was introduced in 1975.In 2003, Griepp et al proposed a new staging system named as International Staging System(ISS) 3,4 which is a simpler one.In our study we used this new staging system and analyzed the significance of various parameters in predicing therapeutic response in myeloma.
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