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Study of homocysteine, total antioxidant capacity, lipoprotein (a) and minerals in steroid sensitive nephrotic syndrome

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Author(s): Angoorbala Bafna | Purnima Dey Sarkar

Journal: International Journal of Biological and Medical Research
ISSN 0976-6685

Volume: 2;
Issue: 2;
Start page: 536;
Date: 2011;
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Keywords: Malon dialdehyde | Lipoprotein(a) | Total antioxidant capacity | Hyperhomicysteinemia | Steriod sensitive | Nephrotic syndrome

ABSTRACT
Several cardiovascular risk factors present in patients with nephrotic syndrome among which are systemic inflammation, hyperhomocysteinemia, increased oxidative stress are considered integral components of the inflammatory responses and also proposed as mediators of plasma homocysteine induced cell damage. We assessed dyslipidemia and its relative contribution in the abnormal oxidative stress, antioxidant status, hyperlipoproteinemia and hyperhomocysteinemia in nephrotic syndrome subjects and in remission stage of nephrotic syndrome. We studied 105 steroid sensitive nephrotic syndromes patients and 99 healthy age matched controls. The patients were observed and their blood samples were analyzed before (pre-treatment group) and after standard corticosteroid induction therapy for one month (post-treatment group).The blood samples were analyzed for quantification of malondialdehyde (an index of lipid per oxidation) homocysteine (a marker of inflammation), lipoprotein (a), lipid profile, total antioxidant capacity, Zinc and Copper. Significantly increased levels of serum total cholesterol, low density lipoprotein cholesterol, lipoprotein (a), malondialdehyde and homocysteine (p

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