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Study of Novel Pyrrole Derivatives

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Author(s): Ashok Prasad | K. S. Nimavat | K. B. Vyas

Journal: International Journal For Pharmaceutical Research Scholars
ISSN 2277-7873

Volume: 1;
Issue: 3;
Start page: 16;
Date: 2012;
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Keywords: 2-(5-((naphthalen-1-yloxy)methyl)-2-thioxo-1 | 3 | 4-oxadiazol-3(2H)-yl)aceto hydrazide | pyrrole | antibacterial and antifungal activities

ABSTRACT
Substituted benzaldehydes on simplistic condensation with 2-(5-((naphthalen-1-yloxy) methyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl)aceto hydrazide(1) was give the consequent N'-arylidene-2-(5-((naphthalen-1-yloxy)methyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl) aceto hydrazide (2a-e) in fine yield. Cyclo condensation of compounds (2a-e) with maleic anhydride yields 2-aryl-5-oxo-1-(2-(5-(phenoxymethyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl) acetamido)-2,5-dihydro-1H-pyrrole-3-carboxylic acid (3a-e). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities.
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