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Study on Effect of Solvents & Nonsolvents on Microspheres of Ciprofloxacin: Coacervation Phase Separation

Author(s): Sunitha S

Journal: Journal of Advanced Scientific Research
ISSN 0976-9595

Volume: 1;
Issue: 2;
Start page: 24;
Date: 2010;
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Keywords: Microspheres | ciprofloxacin | cellulose polymers | coacervation phase separation | solvents | non solvents

The objective of the study was to determine the effect of solvents like acetone, dimethyldigol, 1, 4-dioxan and non-solvents like n-hexane and chloroform on microencapsulation of ciprofloxacin hydrochloride. The microspheres were prepared by following coacervation phase separation using various non- aqueous solvents and non-solvents like solvent evaporation and non-solvent addition method with rate retarding cellulose polymers. Microspheres were characterized for the particle size distribution, wall thickness by scanning electron microscopy (SEM), angle of repose, bulk density, percent drug content, entrapment efficiency and in vitro dissolution studies. Drug excipient compatibility was determined by FTIR and DSC. Accelerated stability studies were also carried out following ICH Guidelines. SEM revealed that microspheres were found spherical, free flowing and porous. The wall thickness and entrapment efficiency was found in between 86.26 μ & 118.77 μ, 62.12% & 98.29 % respectively. The drug release was extended maximum upto 12hours with cellulose acetate using 1-4 dioxan as solvent and upto 12 hours with cellulose acetate phthalate using 1,4-dioxan and dimethyldigol. FTIR and XRD spectra results showed ciprofloxacin hydrochloride was compatible with excipients. The curve fitting data revealed that the release followed first order kinetics and higuchi’s and peppas plots stated non-fickian and diffusion controlled where dimethyldigol and 1,4 dioxan as solvent polymer showed effect over the size and release kinetics.
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