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A study on the inactivated bivalent vaccine prepared from serotypes 1/2a and 4b Listeria monocytogenes for the control of listeriosis in sheep

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Author(s): Bacić Dragan | Obrenović Sonja | Dimitrijević B. | Jonić B. | Žutić Jadranka | Ašanin N.

Journal: Acta Veterinaria
ISSN 0567-8315

Volume: 62;
Issue: 5-6;
Start page: 531;
Date: 2012;
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Keywords: Listeria monocytogenes | vaccine | saponin | sheep

ABSTRACT
In this study, the protective effects of two bivalent inactivated vaccines were evaluated. Vaccines were prepared from Listeria monocytogenes, serotypes 1/2a and 4b, as the most frequent in our and surrounding epidemiological areas. Vaccine A consists of whole L. monocytogenes bacteria cells, inactivated with 0.4% formaldehyde and aluminium hydroxide as a carrier. Vaccine B contains 0.1% saponin in addition to ingredients of vaccine A. Evaluations of these vaccines were performed in 60 sheep, divided into four groups (n=10) with a corresponding negative control group (n=5). After 14 days, boosterisation of all animals was performed. In order to evaluate the immune response, blood samples were obtained every 14 days during the next 6 months. Antibody titres were determined by microaglutitation (MAT) and complement fixation tests (CFT). Comparative analyses of antibody titres, induced by vaccines A and B, show that the latter (with saponine) significantly increased the level of antibody titres (p
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