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STUDY ON INVITRO PERMEATION ENHANCEMENT OF KETOPROFEN BY FORMATION OF SOLID DISPERSION

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Author(s): Saleem M.A | Singh Vishal Kumar | Khalid S | Pange Sudhir | Ahnaf Omair

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 4;
Start page: 134;
Date: 2011;
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Keywords: Ketoprofen | solubility | Invitro dissolution | in vitro permeation | flux

ABSTRACT
Solid dispersions of ketoprofen were prepared by using different water soluble carriers like β-cyclodextrin, PEG 6000, polyvinyl pyrolidone and urea in appropriate concentration to enhance the transdermal flux. The prepared solid dispersions were characterized by IR spectroscopy & DSC suggested no interaction of drug with carriers. The solid dispersions were evaluated for solubility, Invitro dissolution and Invitro permeation through rat skin. The solubility of ketoprofen was enhanced 3-7 times in order of solid dispersion, urea
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