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A study of oxidative stress in paucibacillary and multibacillary leprosy

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Author(s): Jyothi P | Riyaz Najeeba | Nandakumar G | Binitha M

Journal: Indian Journal of Dermatology, Venereology and Leprology
ISSN 0378-6323

Volume: 74;
Issue: 1;
Start page: 80;
Date: 2008;
Original page

Keywords: Leprosy | malondialdehyde | oxidative stress | superoxide dismutase

ABSTRACT
Background: The study and assessment of oxidative stress plays a significant role in the arena of leprosy treatment. Once the presence of oxidative stress is proved, antioxidant supplements can be provided to reduce tissue injury and deformity. Aim: To study oxidative stress in paucibacillary (PB) and multibacillary (MB) leprosy and to compare it with that in a control group. Methods: Fifty-eight untreated leprosy patients (23 PB and 35 MB cases) were studied and compared with 58 healthy controls. Superoxide dismutase (SOD) level as a measure of antioxidant status; malondialdehyde (MDA) level, an indicator of lipid peroxidation; and MDA/SOD ratio, an index of oxidative stress were estimated in the serum. Results: The SOD level was decreased in leprosy patients, especially in MB leprosy. The MDA level was increased in PB and MB leprosy. The MDA/SOD ratio was significantly elevated in MB patients. There was a steady increase in this ratio along the spectrum from tuberculoid to lepromatous leprosy (LL). Conclusion: There is increased oxidative stress in MB leprosy, especially in LL. This warrants antioxidant supplements to prevent tissue injury.
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