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Subacute toxicity study of crude extract of Pisonia alba Span. leaves on rat liver and heart

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Author(s): Supaporn Prasettho | Somsamorn Chittrakarn | Uraporn Vongvatcharanon

Journal: Songklanakarin Journal of Science and Technology
ISSN 0125-3395

Volume: 25;
Issue: 4;
Start page: 515;
Date: 2003;
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Keywords: Saengchan | subacute toxicity | Pisonia alba Span. | histopathological study

ABSTRACT
Pisonia alba Span. is a small tree with single oval leaves and belongs to the Nyctaginaceae family. Subacute toxicity of the crude extract of this plant was investigated. Doses of 0.5, 1 and 2 g/kg of the crude extract were tested in rats via oral feeding administration in a once daily regimen for 45 days. The average body weight of those rats receiving the crude extract was not significantly elevated in comparison with that of the control group. Moreover, the observed behavior of those rats was not different from that of the control group. Histopathological study of the rat liver, however, showed that the average density of necrotic hepatocytes in the treated group was 1.63±0.47 and 1.21±0.33 cell/mm2 with the doses of 1 and 2 g/kg of the crude extract, respectively. These values were significantly lower than those of the control group (2.04±0.68 cell/ mm2) (p
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