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Subclinical haemorrhagic tendency exists in patients with β-thalassaemia major in early childhood

Author(s): Abhishek Maiti | Amartya Chakraborti | Puranjoy Chakraborty | Sanjay Mishra

Journal: Australasian Medical Journal
ISSN 1836-1935

Volume: 5;
Issue: 2;
Start page: 152;
Date: 2012;
Original page

Keywords: Thalassaemia Major | Haemorrhage | Coagulation | Prothrombin Time | Activated Partial Thromboplastin Time.

BackgroundAlterations of coagulation profile have been reported in patients with β-thalassaemia major (β-TM).MethodTo investigate this in the paediatric population, we studied haemostatic parameters in pre-transfusion blood samples from 50 non-splenectomised transfusion-dependent children with β-TM (mean age 6±2.5 years) and in blood from 25 healthy controls.ResultsLaboratory evaluation showed thrombocytopenia in 40%, prolongation of prothrombin time (PT) in 12% and prolongation of activated partial thromboplastin time (APTT) in 6% of the patients. Mean values for PT, APTT and platelet count (PC) were all raised in the patient population compared with the controls. The alteration of coagulation status was significant for PT (p value
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