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Submucosa precedes lamina propria in initiating fibrosis in Oral submucous fibrosis - Evidence based on collagen histochemistry

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Author(s): Anna P. Joseph | R. Rajendran

Journal: Oral & Maxillofacial Pathology Journal
ISSN 0976-1225

Volume: 1;
Issue: 1;
Start page: 3;
Date: 2010;
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Keywords: precancerous condition | submucosa

ABSTRACT
Oral submucous fibrosis is a chronic insidious disease and a well-recognized potentially malignantcondition of the oral cavity. It is a collagen related disorder associated with betel quid chewing andcharacterized by progressive hyalinization of the lamina propria.Objectives: It is traditionally held that in oral submucous fibrosis the hyalinization process starts fromthe lamina propria and progresses to involve the submucosal tissues. However reports of someinvestigators suggest that on the contrary, the fibrosis starts in the submucosa and not in the juxtaepithelium as previously assumed.Methods: A histochemical study comparing the pattern of collagen deposition and hyalinization inearly and advanced cases of oral submucous fibrosis was done using special stain for collagen.Result & Conclusion: The results suggest that in a certain percentage of cases submucosa precedes thelamina propria in initiating fibrosis in this disease. This could have implications on the differencesin clinical presentation, biological progression, neoplastic transformation and responsiveness totreatment.
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