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Succinimides: Synthesis, properties and anticonvulsant activity

Author(s): Banjac Nebojša | Trišović Nemanja | Valentić Nataša | Ušćumlić Gordana | Petrović Slobodan

Journal: Hemijska Industrija
ISSN 0367-598X

Volume: 65;
Issue: 4;
Start page: 439;
Date: 2011;
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Keywords: succinimide | properties | reactivity | sythesis | zarontin | celontin | milontin | anticonvulsant activity | pharmacofor model | lipophilicity | hydrogen bonding

Succinimide is a cycle imide of succinic acid that is present in numerous biologically active compounds including anticonvulsants, antitremor, anti-Parkinson`s agents. This paper describes different ways of synthesis of succinimide-derivatives their physical properties and reactivity. Also, the most widely used succinimide anticonvulsants and the analysis of structure-activity relationships of anticonvulsant drugs in terms of lipophilicity and hydrogen bonding are presented here.
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