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Superantigens in Polyp Tissue of Patients with Chronic Rhino-Sinusitis, A Comparative Study: A Brief Report

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Author(s): M Farhadi | A Tabatabaee | M Shekarabi | S Noorbakhsh | SH Javadi Nia | GH Ghavami

Journal: Tehran University Medical Journal
ISSN 1683-1764

Volume: 70;
Issue: 7;
Start page: 452;
Date: 2012;
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Keywords: ELISA | RT-PCR | Superantigens.

ABSTRACT
Background: Staphylococcus aureus secretes numerous superantigenes which trigger the inflammatory mechanisms of sinus mucosa and cause chronic rhino-sinusitis. This study was designed to evaluate the role of staphylococcus aureus superantigens in polyp tissues of patients with chronic rhino-sinusitis in comparison with a control group.Methods: Polyp tissue samples of 28 patients and mucosal specimens of 19 healthy individuals were evaluated for staphylococcus aureus bacterium superantigens, exotoxins A, B, C and D and TSST-1 with RT-PCR and ELISA methods Rasoul Akram Hospital during 2 years.Results: Polymerase chain reaction (PCR) results revealed that 88.2% of the patients and 45.5% of the controls had at least one type of superantigen (P=0.03). Evaluation of superantigens using ELISA method showed presence of at least one type of superantigen in the nasal samples of all patients and in 35.3% of the controls (P
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