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Suppression of Carrageenan- and Collagen II-Induced Inflammation in Mice by Geranium Oil

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Author(s): Naho Maruyama | Hiroko Ishibashi | Weimin Hu | Shinichiro Morofuji | Shigeharu Inouye | Hideyo Yamaguchi | Shigeru Abe

Journal: Mediators of Inflammation
ISSN 0962-9351

Volume: 2006;
Date: 2006;
Original page

ABSTRACT
To obtain experimental evidence on the therapeutic efficacy of essential oils in aromatherapy for inflammatory diseases, we examined the effects of geranium oil on carrageenan-induced and collagen II-induced inflammation in mice, to assess acute and chronic anti-inflammatory activities of the oil. Single intraperitoneal injection of 5μL of geranium oil clearly suppressed the carrageenan-induced footpaw edema and increase in tissue myeloperoxidase activity, and repeated administration of the oil suppressed collagen-induced arthritis. These results revealed that geranium oil suppressed both acute and chronic inflammatory responses in mice
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