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Surface Engineering of Titania for Excellent Fibroblast 3T3 Cell-Metal Interaction

Author(s): Roshasnorlyza Hazan | Srimala Sreekantan | Adilah Abdul Khalil | Ira Maya Sophia Nordin | Ishak Mat

Journal: Journal of Physical Science
ISSN 1675-3402

Volume: 20;
Issue: 1;
Start page: 35;
Date: 2009;
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Keywords: surface engineering | TiO2 nanotubes | TiO2 thin film | TiO2 foam | cell-metal interaction

The present study is focussed on clarifying the influence of different surface structures (nanotubes, thin film and foam) of titania (TiO2) on the cell interactions of fibroblast (3T3) cells. The nanotubes were prepared by an anodisation process; thin film by a sol-gel method; and foam by the sacrificed polymeric sponge method. Their in vitro bioactivity was investigated by soaking the sample in complete growth medium (RPMI-1640/DMEM) with 3T3 cells. Field Emission Scanning Electron Microscope (FESEM) micrograph and optical density results showed that self-arrayed TiO2 nanotubes strongly enhanced cellular activities, followed by the foam structure and the thin film. Atomic Force Microscope (AFM) results provided evidence that the enhanced cell interaction in nanotubes is associated with the roughness of the surface.
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