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Survey of congenital major malformation in 10,000 newborns

Author(s): "F Khatami | Gh A Mamuri "

Journal: Iranian Journal of Pediatrics
ISSN 2008-2142

Volume: 15;
Issue: 4;
Start page: 315;
Date: 2005;
Original page

Keywords: Major malformations

Background: Congenital major malformations (CMM) are one of the most important causes of admission of newborns in hospitals, and neonatal morbidity and mortality. The incidence of CMM depends age of affected patients. In newborns infants, it is approximately 2-3%. The great majority of CMM occurs sporadic (86%), genetic and exogenic factors both play a role in their occurrence. The aim of this research is to determine the incidence and the associated factors with CMM in Iran. Methods: This is a prospective, analytical, and descriptive study. This study was performed with simple randomized sampling for two year, which involved all live born infants without no anomaly (control group) and all newborns with CMM (patients group). There was a total of 10450 infants. Stillbirth infants and those who died in few hours after birth were excluded and finally 9200 newborns were enrolled in our study. Findings: As a result, the incidence of CMM was approximately 1.8%, isolate malformation (74%) were more common than multiple malformations, musculoskeletal system were the most affected system, and multifactorial inheritance accounted the most etiologic factor. There was no predominance of the two sexes in patients group. Maternal age of over 30 years, consanguineous marriage and positive familial history of CMM, were associated with higher incidence of CMM. Rout of delivery and incidence of prematurity had no CMM incidence rate. Conclusions: Although we got the same result as other investigations, if we enrolled abortions, stillbirth infants and if we used screening tests and genetical studies, the incidence of CMM would be more than 1.8%. Smoking, using drugs, high fever, viral rash and ultrasonography during pregnancy may be probable etiologic factors in CMM. We recommend multicenteral and larger studies for CMM in Iran.
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