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SUSTAINED RELEASE OF NIFEDIPINE FROM MATRIX TABLETS OF ITS SOLID DISPERSIONS EMPLOYING SUPERDISINTEGRANTS

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Author(s): Ramana G | Jyothirmai D | Sri Vaishnavi P

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 9;
Start page: 166;
Date: 2011;
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Keywords: Nifedipine | Solid dispersions | Matrix tablets | Sustained release | channeling agents.

ABSTRACT
The present work was planned with the objective of preparing nifedipine (N) solid dispersions in cross carmellose sodium(CCS) and sodium starch glycholate (SSG) and were investigated with a view to design sustained release tablets of nifedipine. As nifedipine is practically insoluble in water and aqueous fluids; its solid dispersions in CCS and SSG has markedly enhanced the dissolution rate of nifedipine. Matrix tablets formulated employing nifedipine dispersions in CCS and SSG with gum olibanum alone and in combinations with methocel K4M. The matrix tablets gave slow, controlled and complete release over a period of 12 hrs. Drug release from these tablets followed first order kinetics and the release was diffusion controlled. The’ n’ values obtained from Peppas plots were within the range of 0.45 to 0.9, indicates the drug release by both diffusion coupled with erosion. The DSC studies were also indicating the absence of strong interactions between the components and suggesting drug-excipient compatibility in all the formulations examined.
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