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Synergistic Effect of Functionalized Nickel Nanoparticles and Quercetin on Inhibition of the SMMC-7721 Cells Proliferation

Author(s): Guo Dadong | Wu Chunhui | Li Jingyuan | Guo Airong | Li Qingning | Jiang Hui | Chen Baoan | Wang Xuemei

Journal: Nanoscale Research Letters
ISSN 1931-7573

Volume: 4;
Issue: 12;
Start page: 1395;
Date: 2009;
Original page

Keywords: Nickel nanoparticles | Real-time cell electronic sensing (RT-CES) study | MTT assay | Electrochemical analysis | Hepatocellular carcinoma cell line

Abstract The effect of functionalized nickel (Ni) nanoparticles capped with positively charged tetraheptylammonium on cellular uptake of drug quercetin into hepatocellular carcinoma cells (SMMC-7721) has been explored in this study via microscopy and electrochemical characterization as well as MTT assay. Meanwhile, the influence of Ni nanoparticles and/or quercetin on cell proliferation has been further evaluated by the real-time cell electronic sensing (RT-CES) study. Our observations indicate that Ni nanoparticles could efficiently improve the permeability of cancer cell membrane, and remarkably enhance the accumulation of quercetin in SMMC-7721 cells, suggesting that Ni nanoparticles and quercetin would facilitate the synergistic effect on inhibiting proliferation of cancer cells.
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