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Syntheses and Self-assembling Behaviors of Pentagonal Conjugates of Tryptophane Zipper-Forming Peptide

Author(s): Kazunori Matsuura | Kazuya Murasato | Nobuo Kimizuka

Journal: International Journal of Molecular Sciences
ISSN 1422-0067

Volume: 12;
Issue: 8;
Start page: 5187;
Date: 2011;
Original page

Keywords: pentagonal conjugate | tryptophane zipper peptide | self-assembly | nanofiber

Pentagonal conjugates of tryptophane zipper-forming peptide (CKTWTWTE) with a pentaazacyclopentadecane core (Pentagonal-Gly-Trpzip and Pentagonal-Ala-Trpzip) were synthesized and their self-assembling behaviors were investigated in water. Pentagonal-Gly-Trpzip self-assembled into nanofibers with the width of about 5 nm in neutral water (pH 7) via formation of tryptophane zipper, which irreversibly converted to nanoribbons by heating. In contrast, Pentagonal-Ala-Trpzip formed irregular aggregates in water.

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