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SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME 2-PYRAZOLINES DERIVED FROM CHALCONES

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Author(s): Bedia KOÇYİĞİT KAYMAKÇIOĞLU | Elçin E. ORUÇ EMRE | Nagihan BEYHAN | Hale Z. TOKLU | Salih GÜMRU | Feyza ARICIOĞLU

Journal: Anadolu University Journal of Science and Technology - C. Life Sciences and Biotechnology
ISSN 2146-0264

Volume: 1;
Issue: 2;
Start page: 137;
Date: 2011;
Original page

Keywords: Chalcones | 2-Pyrazolines | Thiocarbamide | Anticonvulsant activity

ABSTRACT
In the present study, a series of chalcones were prepared by Claisen Schmidt condensation as starting compounds and 2-pyrazoline derivatives have been synthesized by the reaction of chalcones with thiosemicarbazide. Their structures have been confirmed by IR, ¹H-NMR, mass spectral data and elemental analysis. These synthesized 2-pyrazoline compounds have been tested in vivo anticonvulsant activity by using pentylenetetrazole (PTZ) induced seizure and maximal electroshock (MES) seizure tests at a dose of 50 mg/kg. None of the compounds have in vivo anticonvulsant properties in PTZ test whereas some compounds showed in vivo anticonvulsant activity in MES test. Therefore, 2-pyrazoline compounds have a promising in vivo anticonvulsant activity especially on generalized absence seizures.
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