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Synthesis and Antimicrobial activity 2-chloro-6-methylquinoline Hydrazone derivatives

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Author(s): Sandhya Bawa | Suresh Kumar | Sushma Drabu | Rajiv Kumar

Journal: Journal of Pharmacy and Bioallied Sciences
ISSN 0975-7406

Volume: 1;
Issue: 1;
Start page: 30;
Date: 2009;
Original page

Keywords: 2-Chloro-3-formyl-6-methylquinoline | hydrazones | antibacterial | antifungal activity

ABSTRACT
A series of 2-chloro-6-methylquinoline hydrazones (3a-o) were synthesized by the condensation of substituted acylhydrazines, semicarbazide, thiosemicarbazide and INH with 2-chloro-3-formyl-6-methylquinoline in absolute alcohol.The structures of compounds were established using spectral data and elemental analysis. All the compounds wereevaluated for their antibacterial activity against Escherichia coli (NCTC, 10418), Staphylococcus aureus (NCTC, 65710)and Pseudomonas aeruginosa (NCTC, 10662). Compounds were also tested for antifungal activity aganist Aspergillusniger (MTCC, 281), Aspergillus flavus (MTCC, 277), Monascus purpureus (MTCC, 369) and Penicillium citrinum(NCIM, 768) by cup-plate method.
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