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Synthesis and antimicrobial activity of some new 2-amino pyrimidine derivatives from 1-(3,5-dibromo-2-hydroxy-4 methyl phenyl) ethanone

Author(s): Milind P.Pawar | Kartik Vyas | Nirav M. Shah | Kiran Nimavat

Journal: International Journal For Pharmaceutical Research Scholars
ISSN 2277-7873

Volume: 1;
Issue: 2;
Start page: 398;
Date: 2012;
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Keywords: 2-amino pyridine | 1-(3 | 5-dibromo-2-hydroxy-4 methyl phenyl) ethanone | chalcone | Antimicrobial Activity

The newly synthesized pyrimidine derivatives exhibited moderate to good antimicrobial activity respectto standard drugs. In present investigation, we report the synthesis of 2-amino pyrimidine fromchalcones and guanidine hydrochloride using potassium tetr-butoxide as base. These synthesizedcompounds were characterized on the basis of IR, 1HNMR, Mass spectroscopic data. All synthesizednew 2-amino pyrimidine derivatives were screened for antibacterial and antifungal activity againstdifferent strains as compare to standard drugs Amoxicillin and Griseofulvin. Compound 3a, 3b, 3d, 3gand 3f were found to be active against selected antibacterial and antifungal strains.
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