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SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME HETEROCYCLIC SULFONAMIDE DERIVATIVES SYNTHESIS und antimikrobielle Auswertung einiger HETEROCYCLISCHE Sulfonamidderivaten

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Author(s): Shrinivas S. Kottawar, Santosh V. Goswami, Wamanrao N. Jadhav, Sudhakar R.Bhusare

Journal: Heterocyclic Letters
ISSN 2231-3087

Volume: 3;
Issue: 1;
Start page: 31;
Date: 2013;
Original page

Keywords: Molecular Iodine; p-Toluene sulfonyl chloride; Heterocyclic amines; Sulfonamides; Antimicrobial activity

ABSTRACT
A facile and efficient method for synthesizing sulfonamides was developed using a catalytic amount of molecular iodine in excellent yields. The method showed a generality for substrates including less nucleophilic and sterically hindered heterocyclic amines. The remarkable selectivity under mild and neutral conditions of this commercially available inexpensive catalyst is an attractive feature of this method. In vitro antimicrobial activity was evaluated against the two pathogenic bacterial strains, Escherishia coli, and Staphylococcus aureus and two fungal strains, Rhizopus oryzae and Candida albicans. The compounds have shown moderate to good activity
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