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Synthesis and antimicrobial studies of azetidinone derivatives from sulphadiazine moiety

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Author(s): Ishwar Bhat K1 , Sunil Kumar Mishra1, Jainey. P. James1*, Shastry C. S 1

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 5;
Start page: 1361;
Date: 2011;
Original page

Keywords: Azetidinones | Schiff’s bases | Antibacterial and Antifungal activities.

ABSTRACT
A series of novel Azetidinone derivatives have been synthesized from the intermediate schiff bases. Schiff bases are prepared from sulfadiazine moiety by reacting the hydrazide of the parentcompound with different aromatic aldehydes. Cyclocondensation of schiff’s bases with acetylchloride resulted in the formation of azetidinone derivatives. The structures of these compounds were confirmed by IR, NMR, Mass spectroscopy. Biological studies of the synthesized compounds showed promising antibacterial and antifungal activities.
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