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Synthesis and Antimicrobial Study of Some Schiff Bases of Sulfonamides

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Author(s): Santosh Kumar, Niranjan M S, Chaluvaraju K C, Jamakhandi C M and Dayanand Kadadevar

Journal: Journal of Current Pharmaceutical Research
ISSN 0976-3171

Volume: 1;
Issue: 1;
Start page: 39;
Date: 2010;
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Keywords: Synthesis | Schiff bases | Antimicrobial activity | Sulphanamide.

ABSTRACT
Objective: The purpose of research was to synthesize the better antimicrobial compounds usingDifferent substituted aromatic aldehydes are chosen as the starting material for the synthesis ofSchiff’s Bases with sulfonamide helps to formation of Schiff bases in presences of alcohol and acidicreagent.Material and methods: Melting points of the synthesized compounds were determined by opencapillary and are uncorrected. The purity of the compounds was checked using precoated TLC plates(MERCK, 60F) using chloroform: methanol (8:2) solvent system. The developed chromatographicplates were visualized under UV at 254nm. IR spectra were recorded using KBr on Shimadzu FTIRmodel 8400 spectrophotometer, 1H NMR spectra in DMSO on a BRUKER FT-NMR instrument usingTMS as internal standard.Results : All the synthesized compounds (Ia-Ij) were purified by successive recrystallization usingethanol. The purity of the synthesized compounds was checked by performing TLC. The structures ofthe synthesized compounds were determined on the basis of their FTIR and 1HNMR data. Inaccordance with the data obtained from antimicrobial activity, all the synthesized Schiff bases ofsulphonilamide have shown good activity against the tested microbes. Among these Schiff bases ofsulphanilamide, compound bearing trimethoxy group (If), methoxy group (Ie) and furan ring (Ii) hasshown good activity against all the tested bacteria and fungi.Conclusion: Antibacterial and antifungal activity of the synthesized derivatives was done incomparison with ciprofloxacin and ketoconazole as standard to reveal the potency of synthesizedderivatives. All the 4 selected strains of bacteria and fungi namely B. Subtilis, S. Aureus, E. Coli,S.Typhi and C.Albicans,A. Niger showed sensitivity to all derivatives at higher concentration(200μg/ml) and no sensitivity at lower concentration.
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