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Synthesis and antitubercular screening of novel imidazoline derivatives

Author(s): T.Shalina Begum | U.C.A.Jaleel | P.M.Shafi

Journal: International Journal of Pharmacy and Biomedical Sciences
ISSN 0976-5263

Volume: 04;
Issue: 01;
Start page: 40;
Date: 2013;
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Keywords: Aminoimidazolinone | Antitubercular activity | 4-Arylidene-2-aryl-2- imidazolin-5-ones | Druggability | Tandem reaction

4-Arylidene-2-aryl-2-imidazolin-5-ones were synthesised in good yield by three component condensations of aryl imidic acid ester, glycine ester and aromatic aldehydes in presence of a base. Aminoimidazolinone was also synthesised by tandem reaction between imidic acid ester and glycine ester in presence of a base. These molecules were screened for their tuberculosis activity and drug likeness computationally. All the twelve newly synthesised compounds revealed drug like properties and the aminopyrazinyl imidazolinone was found to be active against tuberculosis

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