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Synthesis of biocompatible multicolor luminescent carbon dots for bioimaging applications

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Author(s): Nagaprasad Puvvada, B N Prashanth Kumar, Suraj Konar, Himani Kalita, Mahitosh Mandal and Amita Pathak

Journal: Science and Technology of Advanced Materials
ISSN 1468-6996

Volume: 13;
Issue: 4;
Start page: 045008;
Date: 2012;
Original page

ABSTRACT
Water-soluble carbon dots (C-dots) were prepared through microwave-assisted pyrolysis of an aqueous solution of dextrin in the presence of sulfuric acid. The C-dots produced showed multicolor luminescence in the entire visible range, without adding any surface-passivating agent. X-ray diffraction and Fourier transform infrared spectroscopy studies revealed the graphitic nature of the carbon and the presence of hydrophilic groups on the surface, respectively. The formation of uniformly distributed C-dots and their luminescent properties were, respectively, revealed from transmission electron microscopy and confocal laser scanning microscopy. The biocompatible nature of C-dots was confirmed by a cytotoxicity assay on MDA-MB-468 cells and their cellular uptake was assessed through a localization study.
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