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SYNTHESIS AND BIOLOGICAL ACTIVITIES OF 2-(FUROYL AMINO)-5- (SUBSTITUTED ARYL)-1,3,4-THIADIAZOLE AND 2-(SUBSTITUTED BENZOYL AMINO)-5-(FURYL)-1,3,4-THIADIAZOLE Synthese und biologische AKTIVIT√ĄTEN VON 2 - (Furoyl AMINO) -5 - (Substituiertem Aryl)-1,3,4-thiadiazol und 2 -(substituiertes Benzoyl AMINO)-5 -(FURYL)-1,3,4-THIADIAZOLE

Author(s): Vijay V Dabholkar and Bharat M Parmar

Journal: Heterocyclic Letters
ISSN 2231-3087

Volume: 1;
Issue: 2;
Start page: 136;
Date: 2011;
Original page

Keywords: 1-(substituted aroyl)-4-furoyl- thiosemicarbazides; PTC; 2-(furoylamino)-5-(substituted aryl)-1 | 3 | 4-thiadiazoles.

1-(substituted aroyl)-4-furoyl- thiosemicarbazides 3(a-e) / 1-furoyl-4-(substituted benzoyl)-thiosemicarbazides 7(a-f) are synthesized under phase transfer catalysis, which on cyclisation with perchloric acid in acetic anhydride furnish perchloric acid salt of 2- (furoylamino)-5-(substituted aryl)-1,3,4-thiadiazoles 4(a-e)/ 2-(substituted benzoylamino)-5- (furyl)-1,3,4-thiadiazoles 8(a-f) respectively. The sulphur and nitrogen containing compounds were screened for anti-microbial activity showed convincing inhibition against E. coli, S. typhi, S. aureus, and B.Substilus bacteria.
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