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SYNTHESIS AND BIOLOGICAL EVALUATION OF OXAZOLONE DERIVATIVES

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Author(s): G Mariappan | Dipankar Sarkar Sarkar | Dipankar Sarkar Sarkar | Rashmi Karki | Rashmi Karki | lipika pandey | lipika pandey | Deepak Kumar | Deepak Kumar

Journal: Journal of Global Pharma Technology
ISSN 0975-8542

Volume: 2;
Issue: 10;
Start page: 28;
Date: 2010;
Original page

Keywords: Oxazolone | Analgesic | Anti-inflammatory.

ABSTRACT
A new series of oxazolone derivatives (OXZ1 to OXZ5) were synthesized. The structures of the synthesized compounds were assigned on the basis of UV, IR, 1H NMR and Mass spectral data. The synthesized compounds were screened for analgesic and anti-inflammatory activities. Among the entire test compounds OXZ1, OXZ2 and OXZ4 showed promising analgesic activity as compared to std. pentazocine. In case of anti-inflammatory activity, all the compounds are active. But OXZ2 was found to be more active as compared to std. aspirin. From both activities, the compound OXZ2 shows significantly more analgesic and anti-inflammatory activity.  All the experimental results were statistically significant at p

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