Academic Journals Database
Disseminating quality controlled scientific knowledge

Synthesis and Biological Evaluation of Potent Antihypertensive Activity: 2-[(Substituted-phenyl amino)-phenyl-methyl]-1-[2'-(1H-tetrazol-5-yl) biphenyl-3-ylmethyl]-1H-benzoimidazol-5-ylamine Derivatives

ADD TO MY LIST
 
Author(s): M. C. Sharma | D. V. Kohli | Smita Sharma

Journal: International Journal of Advances in Pharmaceutical Sciences
ISSN 0976-1055

Volume: 1;
Issue: 3;
Date: 2011;
Original page

Keywords: Benzimidazoles | Biphenyl tetrazole | Angiotension-II | antihypertensive agents

ABSTRACT
Some new 2-[(Substituted-phenyl amino)-phenyl-methyl]-1-[2'-(1H-tetrazol-5-yl) biphenyl-3-ylmethyl]-1H-benzoimidazol-5-ylamine Derivatives were synthesised by 2-( α -hydroxy benzyl) benzimidazole was converted to 2-(α-bromo benzyl) benzimidazole by reacting with Con.Nitric acid, sulphuric acid HBr and Anhydrous ZnCl2 Schiff bases react with ortho position attach biphenyl tetrazole with different substituents amino group cyclocondensation with appropriate reagents. Different from the previously reported and related compounds in that they produce a potent hypertensive effect the compounds synthesised were identified by 1H NMR, 13C NMR, FAB Mass and FT-IR spectroscopic techniques. All compounds studied in this work were screened for their antihypertensive activity by tail cuff method and direct method measurement.Keyword: Benzimidazoles, Biphenyl tetrazole, Angiotension-II, antihypertensive agents
Affiliate Program      Why do you need a reservation system?