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Synthesis and biological evaluation of some novel imidazolinones

Author(s): P.Jyothi | T.Shalina Begum | UCA.Jaleel | Nikhil.P.Anto | Ruby John Anto | PM.Shafi

Journal: International Journal of Pharmacy and Biomedical Sciences
ISSN 0976-5263

Volume: 04;
Issue: 02;
Start page: 78;
Date: 2013;
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Keywords: 4-(Amino aryl) methylene-2-aryl-2-imidazolin-5-ones | Tandem reaction | Trichloride | Druggability | In vitro anticancer activity

Novel 4-(amino aryl)methylene-2-aryl-2-imidazolin-5-ones were synthesised by a tandem reaction between imidic acid ester and glycine ester in presence of a base. Computational analysis was carried out to assess the druggability of the new molecules. In vitro anticancer screening of the aminoimidazolinones and one of their trichlorides were carried out using eight cancer cell lines of various origins. The results successfully establish the synthesised aminoimidazolinone derivatives as novel compounds with pronounced anticancer activity and druglike properties.
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