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SYNTHESIS AND BIOLOGICAL STUDIES OF CHERIMOLACYCLOPEPTIDE E AND ITS N- METHYLATED ANALOG

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Author(s): Himaja M | Siji Rajan | Karigar A.A | Ramana M.V | Napoleon A.A

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 12;
Start page: 270;
Date: 2011;
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Keywords: Cherimolacyclopeptide E | N-methylation | Anthelmintic activity | Insecticidal activity.

ABSTRACT
The N-methyl derivative of Cherimolacyclopeptide E cyclo[Phe-(Dimethyl)Tyr-Pro-Gly-Leu-Gly] was synthesized using solution phase peptide synthesis. The synthesized compound was characterized by spectral data and was evaluated for anthelmintic and insecticidal activities. The compound exhibited potent anthelmintic activity as compared to the standard drug mebendazole.
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