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Synthesis, characterisation and evaluation of antitumour and antifungal activities of transition metal complexes of 4-Pyridine carboxylic acid [(2-hydroxyphenyl)methylene] hydrazide and its 5-methoxy derivative

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Author(s): M.K.Prasanna | K.Pradeep Kumar

Journal: International Journal of Pharmacy and Biomedical Sciences
ISSN 0976-5263

Volume: 04;
Issue: 01;
Start page: 24;
Date: 2013;
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Keywords: Antifungal activity | Antitumour activity | Antimicobacterial agent | Hydrazide hydrazone | Isoniazid

ABSTRACT
4-Pyridinecarboxylic acid [(2-hydroxyphenyl)methylene]hydrazide (L1) and its 5-methoxy derivative (L2) were synthesised by condensing 2-hydroxy benzaldehyde or 2-hydroxy -5- methoxy benzaldehyde with isoniazid. The ligands were characterised by elemental analysis, IR, UV-Visible and NMR spectra. The Cu (II), Zn (II) and Co (II) complexes were synthesised using metal salts with different anions .The composition of the complexes remained the same irrespective of the anionic part. The ligand acts as dibasic tridentate in copper and zinc complexes and monobasic bidentate in cobalt complexes. The ligands show keto-enol tautomerism and the enol form was involved in complexation. Complexes were characterised by elemental analysis, IR, UV-Visible, NMR, ESR and Mass spectra, conductivity and magnetic susceptibility studies .The ligands and complexes were subjected for antitumor and antifungal studies. The antitubercular activities of the ligands were predicted using the PASS prediction server.
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Tango Jona
Tangokurs Rapperswil-Jona