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Synthesis and characterization of an amphiphilic chitosan bearing octyl and methoxy polyethylene

Author(s): Guanghua Liu | Jianqun Gan | Aimin Chen | Qian Liu | Xusheng Zhao

Journal: Natural Science
ISSN 2150-4091

Volume: 02;
Issue: 07;
Start page: 707;
Date: 2010;
Original page

Keywords: Amphiphilic Groups | Chitosan Derivatives | Protection | Hollow Microsperes

An amphiphilic N-octyl-O-methoxy poly (ethylene glycol) chitosan was successfully prepared by grafting successively octyl groups onto amino groups at chitosan’s C-2 position as hydrophobic moieties and methoxy polyethylene glycol (MPEG) groups onto hydroxyl groups at C-6, C-3 as hy-drophilic ones. A certain amount of -NH2 was retained in the structure of chitosan derivatives through protection by phthalic anhydride. The chemical structures and degree of N-and O-substitution of chitosan derivatives were characterized by FTIR, 1H NMR, GPC and elemental analysis, respectively. The amphiphilic property for convenient self-assembly and the preserved -NH2 groups for progressive chemical cross-linking make the resultant Nocyl-O-MPEG chitosan soluble in water and potentially applicable in preparing stable chitosan hollow microspheres, a demanding drug-carrier in medical and pharmaceutical sciences.
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