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Synthesis, Characterization and Antimicrobial Activity of Methyl 1-(-2-amine-alkylcarbonyl) piperidine-4-carboxylate

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Author(s): Bhatt ND | Nimavat K

Journal: International Journal For Pharmaceutical Research Scholars
ISSN 2277-7873

Volume: 2;
Issue: 2;
Start page: 11;
Date: 2013;
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Keywords: Protected amino acid | Isonipecotic acid | CDI | antimicrobial activity

ABSTRACT
A series of Methyl 1-(-2-amine-alkylcarbonyl) piperidine-4-carboxylate derivatives of amino acids (3ae)was synthesized. These new derivative was achieved by treating Isonipecotic acid methyl ester (1)with Boc-protected amino acids (2a-e) using CDI as coupling reagent in MDC at room temperature.Further deprotection with HCl/Dioxane gives the desired product. Structures of the synthesizedcompounds were established on the basis of spectral and elemental analysis. The synthesizedcompounds were screened for antimicrobial activity.
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