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Synthesis, Characterization and Biological Activities of Some New Hypophosphorous Adducts of Acid Hydrazones Derived from 2, 5-Dichloroanilidoacetohydrazide

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Author(s): Raj Narayan Sharma

Journal: Journal of Advanced Scientific Research
ISSN 0976-9595

Volume: 2;
Issue: 2;
Start page: 05;
Date: 2011;
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Keywords: Malonic ester | dianilide | acid hydrazides | hydrazones | hypophosphorous adducts.

ABSTRACT
A new series of hypophosphorous adducts of acid hydrazones have been synthesized by the reaction of 2, 5-dichloroanilidoaceto hydrazide with various Carbonyl Compounds in 42% to 69% yield. Newly synthesized compounds have been tested for their anti-bacterial activity against gram positive bacteria S.albus, S.aureus and gram negative bacteria E.coli and Pseudomonas piosineus. The compound 1, 4, 11, 12, 13 and 15 shown significant activities and compounds 2, 3, 7, 8 and 9 have shown moderate activity. The same compounds were tested for their anti-fungal activity against Candida albicans, Aspergillus niger and Alternaria alternata at concentration of 30 mg/ml using Savored dextrose agar media. The compound 3, 12, 14, 15 shown significant activities and compound 1, 2, 4, 10, 16 and 17 have shown moderate activity against Candida albicans and Aspergillus niger. All the other compounds did not show significant activity against the fungi at the concentration used.
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