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Synthesis, Characterization and Biological Screening of novel N-[2-chloro-4-(trifluromethyl) phenyl]-4-(substituted phenyl)-3, 6-Dimethyl-2-oxo-1, 2, 3, 4-tetrahydropyrimidine-5-carboxamide

Author(s): Nitesh Chauhan | Kiran Nimavat | Kartik Vyas

Journal: International Journal For Pharmaceutical Research Scholars
ISSN 2277-7873

Volume: 1;
Issue: 3;
Start page: 22;
Date: 2012;
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Keywords: Pyrimidine | N-(2-chloro-4-(trifluromethyl) phenyl)-3-oxobutanamide | N-methyl urea | Multi component cyclocondensation

N-[2-chloro-4-(trifluromethyl)phenyl]-4-(substitutedphenyl)-3,6-Dimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide (4a-o) are synthesized. The synthesis of (4a-o) was achieved by acid catalysed cyclocondensation of N-(2-chloro-4-(trifluromethyl) phenyl)-3-oxobutanamide, N-methyl urea and benzaldehydes. The products were characterized by FT-IR, mass spectra, 1H NMR and elemental analyses. The newly synthesized compounds were subjected to various biological activities viz., antimicrobial.
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