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SYNTHESIS, CHARACTERIZATION AND STUDY OF ANTIMICROBIAL ACTIVITY OF 2,6-DITERTIARY BUTYL-1,4-BENZOQUINONE HYDRAZONES

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Author(s): Anees Pangal | Khursheed Ahmed | Sajid Shaikh

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 4;
Issue: 8;
Start page: 172;
Date: 2013;
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Keywords: Hydrazones | 2 | 6-Di-tert-butyl-1 | 4-benzoquinone | antimicrobial activity | Hydrazone derivatives.

ABSTRACT
Four 2,6-di-tert-butyl-1,4-benzoquinone hydrazones have been synthesized viz. A1, A2, A3 and A4. The purity was checked using HPLC. These compounds were characterized by FTIR and H1-NMR and they shows a prominent absorption of -(C=N-) in FTIR. It also shows a common peak of oleifinic proton at 6.50 Hz. These hydrazones were tested for their antimicrobial activity against Gram +ve and Gram –ve bacteria. A3 was found to be active at a minimum concentration of 50 μg•mL–1 where as A2 was inactive.
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